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The full list of medical papers

Which published NAD+ papers support these facts?

The numbered marks on each page lead to this list. You can see who ran each test and what kind of test it was.

Back to the researchRead the FAQ

How can you use these NAD+ references?

A repair bill is easier to trust when you can check every part. A medical claim also needs a paper behind it.

A number such as [1] leads to one paper in the list below. The entry names the people who ran the test and the journal that printed it.

Some papers tested nicotinamide mononucleotide, called NMN. Others tested nicotinamide riboside, called NR, or watched cells and animals.

The cited references keep those kinds of work separate. When you want to check a claim for yourself, the list shows the dose, whether researchers tested people or mice, and exactly what changed during the work in question.

  1. Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. ↗
  2. Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016;23(6):1127-1139. ↗
  3. Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43. ↗
  4. Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. 2019;9(1):9772. ↗
  5. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. ↗
  6. Nacarelli T, Lau L, Fukumoto T, Zundell J, Fatkhutdinov N, Wu S, Aird KM, Iwasaki O, Kossenkov AV, Schultz D, Noma KI, Baur JA, Schug Z, Tang HY, Speicher DW, David G, Zhang R. NAD+ metabolism governs the proinflammatory senescence-associated secretome. Nat Cell Biol. 2019;21(3):397-407. ↗
  7. Basse AL, Isidor MS, Winther S, Skjoldborg NB, Murholm M, Andersen ES, Pedersen SB, Wolfrum C, Quistorff B, Hansen JB. NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner. Proc Natl Acad Sci U S A. 2023;120(15):e2220102120. ↗
  8. Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. ↗
  9. Houtkooper RH, Cantó C, Wanders RJ, Auwerx J. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev. 2010;31(2):194-223. ↗
  10. Groth B, Venkatakrishnan P, Lin SJ. NAD+ Metabolism, Metabolic Stress, and Infection. Front Mol Biosci. 2021;8:686412. ↗
  11. Kar A, Mehrotra S, Chatterjee S. CD38: T Cell Immuno-Metabolic Modulator. Cells. 2020;9(7):1716. ↗
  12. Aleo MF, Giudici ML, Sestini S, Danesi P, Pompucci G, Preti A. Metabolic fate of extracellular NAD in human skin fibroblasts. J Cell Biochem. 2001;80(3):360-366. ↗
  13. Cheng L, Deepak RNVK, Wang G, Meng Z, Tao L, Xie M, Chi W, Zhang Y, Yang M, Liao Y, Xu R, Fan H, Jiang H, Han W, Bai L, Wang Q. Hepatic mitochondrial NAD+ transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis. Hepatology. 2023;78(6):1828-1842. ↗
  14. Vinten KT, Trętowicz MM, Coskun E, van Weeghel M, Cantó C, Zapata-Pérez R, Janssens GE, Houtkooper RH. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nat Metab. 2025;7(10):1974-1990. ↗
  15. Chini CCS, Cordeiro HS, Tran NLK, Chini EN. NAD metabolism: Role in senescence regulation and aging. Aging Cell. 2024;23(1):e13920. ↗